Ĭhen XY, Low HR, Loi XY, Merel L, Mohd Cairul Iqbal MA (2019) Fabrication and evaluation of bacterial nanocellulose/poly (acrylic acid)/graphene oxide composite hydrogel: characterizations and biocompatibility studies for wound dressing. īarhoum A, Pal K, Rahier H, Uludag H, Kim IS, Bechelany M (2019) Nanofibers as new-generation materials: from spinning and nano-spinning fabrication techniques to emerging applications. īagher Z et al (2019) Wound healing with alginate/chitosan hydrogel containing hesperidin in rat model. Īydemir Sezer U, Sahin İ, Aru B, Olmez H, Yanıkkaya Demirel G, Sezer S (2019) Cytotoxicity, bactericidal and hemostatic evaluation of oxidized cellulose microparticles: structure and oxidation degree approach. Int J Low Extrem Wounds 13:180–190Īlam HB, Burris D, DaCorta JA, Rhee P (2005) Hemorrhage control in the battlefield: role of new hemostatic. Īgrawal P, Soni S, Mittal G, Bhatnagar A (2014) Role of polymeric biomaterials as wound healing agents. J Biomed Mater Res Part B Appl Biomater 87B:264–285. Graphic abstractĪbraham LC, Zuena E, Perez-Ramirez B, Kaplan DL (2008) Guide to collagen characterization for biomaterial studies. The findings of this study indicate that the addition of OF into CG increased the clotting capability as well as the bio-absorbability of the biocomposite sponges. The biocomposite sponge fabricated by addition of 30% OF suspension into CG solution showed the lowest amount of bleeding and the highest bio-absorbability after 21 days. To assess the in vivo bio-absorbability of the samples, the sponges were implanted in the liver for 21 days and the volume of the repaired tissue was measured from histopathological analysis. The amount of bleeding was measured after 10 s on hepatic trauma in a rat model. Addition of OF increased the swelling ratio of CG sponges. Fourier transform infrared spectroscopy proved the formation of carboxyl groups on cellulose fibers.
The cellulose fibers were oxidized by 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO).
Chitosan/gelatin (CG) composite sponges containing oxidized cellulose fibers (OF) crosslinked with tannic acid were fabricated by freeze-drying as hemostatic agents.
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